Inclusion Criteria:

* Signed informed consent form 18 years of age or older

* Documented diagnosis of ulcerative colitis (UC) of at least 12 weeks prior to screening

* Moderately to severely active UC as per the modified Mayo score

* Demonstrated inadequate response to or intolerance of conventional therapy and/or advanced therapy as defined in the protocol

Exclusion Criteria:

* Participants with current or prior diagnosis of fulminant colitis and/or toxic megacolon

* UC limited to rectum only or to less than (<) 15 centimeters (cm) of colon

* Presence of a stoma

* Presence or history of fistula

* History of extensive colonic resection (example, <30 cm of colon remaining)

* Diagnosis of indeterminate colitis, microscopic colitis, ischemic colitis, Crohn's colitis or clinical findings suggestive of Crohn's disease