A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis (ICONIC-ADVANCE 2)
Last Updated   May 8, 2024 - 21:00
OVERVIEW
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Gender
all -
Age
years -
Phase
phase 3The drug or treatment is given to large groups of people to confirm its effectiveness, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely. -
Sites
sites -
Status
Recruiting
SUMMARY
The purpose of the study is to evaluate how effective JNJ-77242113 is in participants with moderate to severe plaque psoriasis compared to placebo and deucravacitinib.
CONDITIONS
- plaque psoriasis
ELIGIBILITY
Inclusion Criteria:
* Diagnosis of plaque psoriasis, with or without psoriatic arthritis (PsA), for at least 26 weeks prior to the first administration of study intervention
* Total body surface area (BSA) greater than or equal to (>=)10 percent (%) at screening and baseline
* Total psoriasis area and severity index (PASI) >=12 at screening and baseline
* Total investigator global assessment (IGA) >=3 at screening and baseline
* Candidate for phototherapy or systemic treatment for plaque psoriasis
Exclusion Criteria:
* Nonplaque form of psoriasis (for example, erythrodermic, guttate, or pustular)
* Current drug-induced psoriasis (for example, a new onset of psoriasis or an exacerbation of psoriasis from beta blockers, calcium channel blockers, or lithium)
* A current diagnosis or signs or symptoms of severe, progressive, or uncontrolled renal, liver, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic, psychiatric, or metabolic disturbances
* Known allergies, hypersensitivity, or intolerance to JNJ-77242113, deucravacitinib or to any of the excipients or components of the study intervention
* Major surgical procedure, (for example, requiring general anesthesia) within 8 weeks before screening, or will not have fully recovered from surgical procedure, or has a surgical procedure planned during the time the participant is expected to participate in the study
DETAILS
LOCATIONS
Country (11) | City or Province (111) | Status |
United States | Arlington, TX Arlington Research Center, Inc. |
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United States | Bay City, MI Great Lakes Research Group |
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United States | Bexley, OH Bexley dermatology research |
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United States | Bountiful, UT Cope Family Medicine - Ogden Clinic |
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United States | Brighton, MA Metro Boston Clinical Partners |
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United States | Caledonia, MI The Derm Institute of West Michigan |
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United States | Canton, MI Hamzavi Dermatology |
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United States | Charleston, SC Clinical Research Center of the Carolinas LLC |
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United States | Douglasville, GA Southeast Dermatology Specialists |
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United States | Encinitas, CA California Dermatology & Clinical Research Institute |
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United States | Encino, CA T Joseph Raoof Md Inc |
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United States | Greenville, SC Palmetto Clinical Trial Services, LLC |
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United States | Kirksville, MO Cleaver Dermatology |
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United States | Los Angeles, CA Wallace Medical Group, Inc. |
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United States | Louisville, KY Skin Sciences, PLLC |
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United States | Methuen, MA ActivMed Practices and Research |
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United States | Miami, FL Bioclinical Research Alliance Inc. |
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United States | Miami, FL Miami Dermatology And Laser Institute |
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United States | Norfolk, VA Virginia Dermatology Skin Cancer Center Pllc |
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United States | Oceanside, CA Dermatologist Medical Group of North County, Inc. |
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United States | Owensboro, KY Qualmedica Research |
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United States | Philadelphia, PA Paddington Testing Co, Inc. |
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United States | Phoenix, AZ Alliance Dermatology and MOHS Center P C |
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United States | Portland, OR Oregon Dermatology & Research Center |
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United States | Rockville, MD DermAssociates, PC |
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United States | Rolling Meadows, IL Arlington Dermatology |
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United States | San Antonio, TX Dermatology Clinical Research Center of San Antonio |
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United States | Springville, UT Springville Dermatology CCT Research |
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United States | Tampa, FL Forcare Clinical Research Inc |
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United States | Troy, MI Somerset Skin Centre |
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United States | Tulsa, OK Essential Medical Research |
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United States | Webster, TX Center for Clinical Studies |
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United States | West Valley City, UT Kalo Clinical Research |
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Taiwan | Kaohsiung Kaohsiung Medical University Chung-Ho Memorial Hospital |
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Taiwan | Kaohsiung Kaohsiung Veterans General Hospital |
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Taiwan | Taichung Chung Shan Medical University Hospital |
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Taiwan | Taichung Taichung Veterans General Hospital |
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Taiwan | Tainan National Cheng Kung University Hospital |
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Taiwan | Taipei Taipei Medical University |
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Taiwan | Taipei Taipei Municipal Wanfang Hospital |
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Spain | Alcorcon, MD Hosp. Univ. Fundacion Alcorcon |
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Spain | Barcelona, BA Hosp. Clinic de Barcelona |
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Spain | Manises, VC Hosp. de Manises |
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Spain | Salamanca, SL Hosp. Clinico Univ. de Salamanca |
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Spain | Santiago de Compostela Clinica Gaias |
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Spain | Santiago de Compostela Hosp. Clinico Univ. de Santiago |
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Spain | Sevilla Hosp. Ntra. Sra. de Valme |
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Spain | Sevilla Hosp. Virgen Macarena |
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Spain | Villajoyosa, AC Hosp. de La Marina Baixa |
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Spain | Zaragoza, ZR Hosp. Clinico Univ. Lozano Blesa |
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South Korea | Ansan-si, 41 Korea University Ansan Hospital |
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South Korea | Anyang-si, 41 Hallym University Sacred Heart Hospital |
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South Korea | Bucheon si, 41 The Catholic University of Korea Bucheon St Mary s Hospital |
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South Korea | Gwangju, 46 Chosun university hospital |
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South Korea | Seongnam, 41 CHA Bundang Medical Center, CHA University |
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South Korea | Seoul Asan Medical Center |
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South Korea | Seoul Korea University Guro Hospital |
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Romania | Craiova Centrul Medical Vitaplus |
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Romania | Iasi Sc Iasiprest Srl |
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Romania | Timisoara, TM New Derm Clinic |
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Poland | Bialystok Renew Clinic |
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Poland | Katowice Care Clinic |
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Poland | Katowice Centrum Medyczne Angelius Provita |
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Poland | Kielce Prywatny Gabinet Dermatologiczny Elzbieta Klujszo |
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Poland | Krakow Diamond Clinic |
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Poland | Krakow Jagiellonskie Centrum Innowacji |
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Poland | Krakow Krakowskie Centrum Badan Klinicznych |
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Poland | Krakow SGD s.c. |
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Poland | Olsztyn Etyka Osrodek Badan Klinicznych |
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Poland | Warsaw Royalderm Agnieszka Nawrocka |
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Poland | Warszawa Carpe Diem Centrum Medycyny Estetycznej |
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Poland | Warszawa Synexus Polska Sp z o o Oddzial w Warszawie |
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Poland | Wrocław WroMedica I.Bielicka, A.Strzałkowska s.c. |
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Hungary | Budapest Uno Medical Trials Ltd. |
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Hungary | Gyongyos Bugat Pal Korhaz |
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Hungary | Gyula Synexus Magyarorszag Kft |
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Hungary | Kecskemet Bacs Kiskun Varmegyei Oktatokorhaz |
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Hungary | Zalaegerszeg Synexus Magyarorszag Kft |
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Germany | Augsburg Hautarztpraxis Dr. Mihaescu |
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Germany | Bad Bentheim Fachklinik Bad Bentheim |
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Germany | Berlin, BE CRS Clinical Research Services Berlin GmbH |
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Germany | Bochum Niesmann & Othlinghaus GbR |
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Germany | Dresden, SN Medizinische Fakultat Carl Gustav Carus Technische Universitat Dresden |
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Germany | Dulmen Hautzentrum Dulmen |
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Germany | Dusseldorf Privatpraxis Dr. Hilton & Partner |
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Germany | Friedrichshafen, BW Derma-Study-Center Friedrichshafen GmbH |
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Germany | Hamburg, HH Eurofins bioskin GmbH |
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Germany | Heidelberg, BW Universitaetsklinikum Heidelberg |
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Germany | Mahlow, BB Hautarztpraxis |
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Germany | Mainz, RP Universitätsmedizin der Johannes Gutenberg-Universität Mainz |
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Germany | Merzig, SL Hautmedizin Saar |
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Germany | Muenster Universitaetsklinikum Muenster |
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Germany | Oldenburg, NI Klinikum Oldenburg |
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Germany | Witten Hautarztpraxis |
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Canada | London, ON Lovegrove Dermatology |
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Canada | Markham, ON Lynderm Research Inc. |
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Canada | Mississauga, ON DermEdge Research |
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Canada | Montreal, QC Innovaderm Research Inc. |
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Canada | Peterborough, ON Skin Centre for Dermatology |
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Canada | Quebec Centre De Recherche Dermatologique Du Quebec Metropolitain |
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Canada | Surrey, BC Dr. Chih-ho Hong Medical |
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Canada | Toronto, ON North York Research Inc |
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Canada | Toronto, ON Toronto Research Centre |
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Canada | Windsor, ON XLR8 Medical Research |
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Canada | Winnipeg, MB Wiseman Dermatology Research Inc. |
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Brazil | Santo Andre, SP Fundacao do ABC - Centro Universitario FMABC |
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Australia | Benowa, QLD The Skin Centre |
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Australia | Kogarah, NSW Premier Specialists |
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Australia | Melbourne, VIC The Alfred Hospital |
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Australia | Mitcham, VIC ISHI dermatology |
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Australia | Parkville, VIC Royal Melbourne Hospital |
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