A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy (OrigAMI-3)
Last Updated May 14, 2025
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61186372COR3002
OVERVIEW
-
Sexes Eligible for Study
all -
Age
years -
Phase
phase 3 -
Sites
Sites -
Status
Recruiting
SUMMARY
The purpose of this study is to compare how long the participants are disease-free (progression-free survival) and and the length of time until a participant dies (overall survival), when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, and irinotecan hydrochloride (FOLFIRI) versus either cetuximab or bevacizumab and FOLFIRI given to participants with Kirsten rat sarcoma viral oncogene/ neuroblastoma RAS viral oncogene homolog (KRAS/ NRAS) and v-raf murine sarcoma viral oncogene homolog B (BRAF) wild-type recurrent, unresectable or metastatic colorectal cancer who have previously received chemotherapy.
CONDITIONS
- Colorectal Neoplasms
ELIGIBILITY
Inclusion Criteria:
* Have histologically or cytologically confirmed adenocarcinoma of the colon or rectum. Participants must have recurrent, unresectable or metastatic disease
* Be diagnosed to have KRAS, NRAS, and BRAF wild-type (WT) tumor as determined by local testing
* Mu
DETAILS
LOCATIONS
Locations in:
United States, Australia, Belgium, Brazil, China, France, Germany, Hong Kong, Hungary, India, Israel, Italy, Japan, South Korea, Malaysia, Mexico, Netherlands, Poland, Puerto Rico, Romania, Spain, Sweden, Taiwan, Thailand, Türkiye, United Kingdom
| Country (26) | City or Province (168) | Status |
| United States | Chandler Ironwood Cancer and Research Center |
RECRUITING
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| United States | Jonesboro St. Bernard's Medical Center |
RECRUITING
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| United States | Bakersfield CBCC Global Research |
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| United States | Los Alamitos Cancer and Blood Specialty Clinic |
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| United States | Los Angeles USC Norris Comprehensive Cancer Center |
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| United States | Santa Rosa Providence Medical Foundation |
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| United States | Torrance Torrance Memorial Physicians Network |
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| United States | Aurora University of Colorado Denver Anschultz Medical Campus |
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| United States | Norwich Eastern Connecticut Hematology & Oncology Assoc. |
RECRUITING
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| United States | Miami Beach Mount Sinai Medical Center Campus |
RECRUITING
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| United States | Orlando AdventHealth Cancer Institute |
RECRUITING
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| United States | Atlanta Grady Memorial Hospital |
RECRUITING
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| United States | Atlanta Winship Cancer Institute Emory University |
RECRUITING
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| United States | Baton Rouge Mary Bird Perkins Cancer Center |
RECRUITING
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| United States | Baltimore MedStar Franklin Square Medical Center |
RECRUITING
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| United States | Grand Rapids Cancer And Hematology Centers of Western Michigan PC |
RECRUITING
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| United States | Hattiesburg Hattiesburg Clinic |
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| United States | Saint Louis Washington University School Of Medicine |
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| United States | Omaha Nebraska Cancer Specialists |
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| United States | East Brunswick Astera Cancer Care |
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| United States | Shirley New York Cancer and Blood Specialists |
RECRUITING
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| United States | Philadelphia Fox Chase Cancer Center |
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| United States | Nashville Tennessee Oncology |
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| United States | Houston MD Anderson Cancer Center |
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| United States | Temple Scott And White Memorial Hospital |
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| United States | Lacey Providence Regional Cancer System |
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| Australia | Concord Concord Hospital |
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| Australia | Heidelberg Warringal Private Hospital |
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| Australia | South Woodville Queen Elizabeth Hospital |
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| Australia | St Albans Western Health Sunshine Hospital |
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| Belgium | Anderlecht Institut Jules Bordet |
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| Belgium | Edegem UZ Antwerpen |
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| Belgium | Gent AZ Maria Middelares |
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| Belgium | Haine Saint Paul La Louviere Jolimont |
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| Belgium | Kortrijk Az Groeninge |
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| Belgium | Leuven Universitair Ziekenhuis Leuven |
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| Brazil | Barretos Fundacao Pio XII |
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| Brazil | Caxias do Sul Fundacao Universidade de Caxias do Sul |
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| Brazil | Jau Fundacao Doutor Amaral Carvalho |
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| Brazil | Salvador Hospital Santa Izabel Santa Casa de Misericordia da Bahia |
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| Brazil | Sao Jose do Rio Preto Fundacao Faculdade Regional De Medicina S Jose Rio Preto Hospital De Base |
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| Brazil | Sao Paulo Fundacao Antonio Prudente A C Camargo Cancer Center |
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| Brazil | Vitoria Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia |
RECRUITING
|
| China | Beijing Peking University First Hospital |
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|
| China | Beijing Beijing Friendship Hospital Capital Medical University |
RECRUITING
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| China | Beijing Beijing Cancer Hospital |
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| China | Chengdu West China Hospital of Sichuan University |
RECRUITING
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| China | Ganzhou Ganzhou Cancer Hospital |
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| China | Guangzhou Sun Yat Sen University Cancer Center |
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| China | Guangzhou The Sixth Affiliated Hospital Sun Yat sen University |
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| China | Guangzhou Guangdong Provincial People's Hospital |
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| China | Hangzhou The Second Affiliated Hospital of Zhejiang University |
RECRUITING
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| China | Hangzhou Zhejiang Cancer Hospital |
RECRUITING
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| China | Huizhou Huizhou Central People's Hospital |
RECRUITING
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| China | Lanzhou Gansu Provincial Cancer Hospital |
RECRUITING
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| China | Nanchang The First Affiliated Hospital of NanChang University |
RECRUITING
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| China | Shanghai Fudan University Shanghai Cancer Center |
RECRUITING
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| China | Tianjin Tianjin Medical University Cancer Institute and Hospital |
RECRUITING
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| China | Wuhan Hubei Cancer Hospital |
RECRUITING
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| France | Avignon Cedex 9 Institut Sainte Catherine |
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| France | Pessac Hopital Haut Leveque |
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| France | Poitiers Cedex CHU De Poitiers |
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| Germany | Berlin Charite Universitatsmedizin Berlin Campus Virchow Klinikum |
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| Germany | Frankfurt am Main Krankenhaus NorthWest |
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| Germany | Munich Klinikum der Universitaet Muenchen |
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| Hong Kong | Shatin Prince Of Wales Hospital |
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| Hungary | Eger Markhot Ferenc Oktatokorhaz es Rendelointezet |
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| Hungary | Pecs Pecsi Tudomanyegyetem |
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| India | Delhi Rajiv Gandhi Cancer Institute and Research Centre |
RECRUITING
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| India | Hyderabad Asian Institute Of Gastroenterology |
RECRUITING
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| India | Kolkata B P Poddar Hospital and Medical research Limited |
RECRUITING
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| India | Mumbai Tata Memorial Hospital |
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| India | Pune Deenanath Mangeshkar Hospital and Research Centre |
RECRUITING
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| India | Vellore Christian medical |
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| Israel | Beer Yaakov Yitzhak Shamir Medical Center |
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| Israel | Haifa Rambam Medical Center |
RECRUITING
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| Israel | Jerusalem Hadassah Medical Center |
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| Israel | Petach Tikva Rabin Medical Center |
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| Israel | Ramat Gan Sheba Medical Center |
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| Israel | Tel Aviv Yafo Tel Aviv Sourasky Medical Center |
RECRUITING
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| Israel | Tel Aviv Assuta MC |
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| Italy | Milano Istituto Dei Tumori Di Milano |
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| Italy | Padova Istituto Oncologico Veneto - IRCCS |
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| Italy | Pisa Azienda Ospedaliero Universitaria Pisana |
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| Italy | Rozzano Istituto Clinico Humanitas |
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| Italy | Udine Azienda Sanitaria Universitaria Friuli Centrale ASU FC |
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| Japan | Chiba Chiba Cancer Center |
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| Japan | Chuo Ku National Cancer Center Hospital |
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| Japan | Kashiwa National Cancer Center Hospital East |
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| Japan | Nagoya Shi Aichi Cancer Center |
RECRUITING
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| Japan | Osaka City Osaka International Cancer Institute |
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| Japan | Osaka Sayama shi Kindai University Hospital |
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| Japan | Osaka-Shi National Hospital Organization Osaka National Hospital |
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| Japan | Suita-shi Osaka University Hospital |
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| Japan | Tokyo The Cancer Institute Hospital of JFCR |
RECRUITING
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| South Korea | Daegu Kyungpook National University Chilgok Hospital |
RECRUITING
|
| South Korea | Seoul Korea University Anam Hospital |
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| South Korea | Seoul Seoul National University Hospital |
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| South Korea | Seoul Severance Hospital Yonsei University Health System |
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| South Korea | Seoul Asan Medical Center |
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| South Korea | Seoul Samsung Medical Center |
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| South Korea | Seoul The Catholic University of Korea Seoul St Mary s Hospital |
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| Malaysia | Georgetown Hospital Pulau Pinang |
RECRUITING
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| Malaysia | Ipoh Hospital Raja Permaisuri Bainun |
RECRUITING
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| Malaysia | Kuala Lumpur Hospital Kuala Lumpur |
RECRUITING
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| Malaysia | Kuala Lumpur University Malaya Medical Centre |
RECRUITING
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| Malaysia | Kuching Hospital Umum Sarawak |
RECRUITING
|
| Malaysia | Putrajaya Institut Kanser Negara Clinical Research Center |
RECRUITING
|
| Mexico | Chihuahua Centro Oncologico de Chihuahua |
RECRUITING
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| Mexico | Ciudad de Mexico Centro Oncologico Personalizado Cope S De R L De C V |
RECRUITING
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| Mexico | Guadalajara Actualidad Basada En La Investigacion Del Cancer |
RECRUITING
|
| Mexico | Puebla Oncocenter |
RECRUITING
|
| Mexico | Queretaro Cuidados Oncologicos |
RECRUITING
|
| Mexico | Queretaro Health Pharma Queretaro SA de CV |
RECRUITING
|
| Netherlands | Amersfoort Meander Medisch Centrum |
RECRUITING
|
| Netherlands | Nijmegen Radboud University Medical Center |
RECRUITING
|
| Netherlands | Rotterdam Erasmus MC |
RECRUITING
|
| Netherlands | Tilburg ETZ TweeSteden |
RECRUITING
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| Poland | Biala Podlaska Wojewodzki Szpital Specjalistyczny |
RECRUITING
|
| Poland | Bialystok Bialostockie Centrum Onkologii im Marii Sklodowskiej Curie w Bialymstoku |
RECRUITING
|
| Poland | Brzozow Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza |
RECRUITING
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| Poland | Gdansk Uniwersyteckie Centrum Kliniczne |
RECRUITING
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| Poland | Gliwice Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut BadawczyOddz w Gliwicach |
RECRUITING
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| Poland | Lodz Instytut Centrum Zdrowia Matki Polki |
RECRUITING
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| Poland | Olsztyn SPZOZ Ministerstwa Spraw Wewnetrznych z Warminsko Mazurskim Centrum Onkologii w Olsztynie |
RECRUITING
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| Poland | Opole SPZOZ Opolskie Centrum Onkologii im. Prof. Tadeusza Koszarowskiego |
RECRUITING
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| Poland | Warszawa Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy |
RECRUITING
|
| Puerto Rico | San Juan Pan American Center for Oncology Trials LLC |
RECRUITING
|
| Romania | Brasov Centrul Medical Unirea SRL |
RECRUITING
|
| Romania | Bucuresti Ponderas Academic Hospital |
RECRUITING
|
| Romania | Craiova Clinica de Oncologie Sf Nectarie |
RECRUITING
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| Spain | Barcelona Hosp. de La Santa Creu I Sant Pau |
RECRUITING
|
| Spain | Barcelona Hosp Univ Vall D Hebron |
RECRUITING
|
| Spain | Madrid Hosp. Gral. Univ. Gregorio Maranon |
RECRUITING
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| Spain | Madrid Hosp. Univ. Ramon Y Cajal |
RECRUITING
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| Spain | Madrid Hosp. Univ. 12 de Octubre |
RECRUITING
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| Spain | Pamplona Clinica Univ. de Navarra |
RECRUITING
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| Spain | Sevilla Hosp. Virgen Del Rocio |
RECRUITING
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| Spain | Valencia Hosp. Clinico Univ. de Valencia |
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| Sweden | Gothenburg Sahlgrenska Universitetssjukhuset |
RECRUITING
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| Sweden | Lund Skanes universitetssjukhus |
RECRUITING
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| Sweden | Stockholm Sodersjukhuset |
RECRUITING
|
| Sweden | Stockholm Karolinska Universitetssjukhuset |
RECRUITING
|
| Sweden | Uppsala Uppsala University |
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|
| Taiwan | Kaohsiung City Chang Gung Memorial Hospital |
RECRUITING
|
| Taiwan | Kaohsiung Kaohsiung Medical University Chung Ho Memorial Hospital |
RECRUITING
|
| Taiwan | Taichung Taichung Veterans General Hospital |
RECRUITING
|
| Taiwan | Tainan National Cheng Kung University Hospital |
RECRUITING
|
| Taiwan | Taipei National Taiwan University Hospital |
RECRUITING
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| Taiwan | Taipei Taipei Veterans General Hospital |
RECRUITING
|
| Taiwan | Taoyuan Linkou Chang Gung Memorial Hospital |
RECRUITING
|
| Thailand | Bangkok Ramathibodi Hospital |
RECRUITING
|
| Thailand | Bangkok Siriraj Hospital |
RECRUITING
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| Thailand | Chiang Mai Chiang Mai University |
RECRUITING
|
| Thailand | Songkhla Songklanagarind hospital |
RECRUITING
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| Türkiye | Ankara Gulhane Egitim ve Arastirma Hastanesi |
RECRUITING
|
| Türkiye | Ankara Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital |
RECRUITING
|
| Türkiye | Ankara Gazi University Hospital |
RECRUITING
|
| Türkiye | Istanbul Bakirkoy Training and Research Hospital |
RECRUITING
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| Türkiye | İstanbul Marmara University Pendik Training Hospital |
RECRUITING
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| Türkiye | Konya Necmettin Erbakan University Meram Medical Faculty |
RECRUITING
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| Türkiye | Sakarya Sakarya University Training and Research Hospital |
RECRUITING
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| United Kingdom | Hull Castle Hill Hospital |
RECRUITING
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| United Kingdom | Leeds St James University Hospital |
RECRUITING
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| United Kingdom | London St Bartholomew's Hospital |
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| United Kingdom | London University College Hospital |
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| United Kingdom | London Royal Marsden Hospital |
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| United Kingdom | Northwood Mount Vernon Cancer Centre |
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Geo Locations
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